In this study, a series of Li0.43Zn0.27Ti0.13Fe2.17O4 ferrites were successfully synthesized by solid-state reaction method at 920 ℃ employing low melting point V2O5 as sintering aid. The X-ray diffraction (XRD) studies demonstrated that all samples exhibited spinel phase. Microscopic image analysis revealed that both the grain growth and uniformity were significantly promoted. The average grain size was increased from 0.65 µm to 4.53 µm when V2O5 was increased from 0.0 wt% to 2.4 wt%. In terms of the magnetic properties, the saturation magnetization (4πMs) of the samples increased from 2915 Gs to 3434 Gs, the coercivity (Hc) decreased from 848.3 A/m to 242.2 A/m, and the ferromagnetic resonance linewidth (ΔH) decreased from 963 Oe to 543 Oe. It could be noted that the proper addition of V2O5 is the key to optimizing the microstructure and magnetic properties of LiZnTi microwave ferrite. Therefore, as an effective additive, V2O5 can promote the development of low temperature co-fired ferrites. •Microstructure of LiZnTi ferrite was improved by V2O5 doping. Grain growth and uniformity were obviously promoted.•Magnetic properties, including 4πMs and Hc, were optimized by V2O5 doping.•Ferromagnetic resonance linewidth (ΔH) was decreased significantly by V2O5 doping.