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March, C J; Mosley, B; Larsen, A; Cerretti, D P; Braedt, G; Price, V; Gillis, S; Henney, C S; Kronheim, S R; Grabstein, K
Nature (London), 06/1985, Letnik: 315, Številka: 6021Journal Article
Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-1 alpha and IL-1 beta), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity.
