The authors report on three patients who received full-face transplants in procedures aimed at functional restoration. Six months after transplantation, facial appearance and function were improved and glucocorticoids had been successfully withdrawn in all patients. Facial transplantation is a single, complex operation intended to transform severely deformed features to near-normal appearance and function with the use of techniques that conventional plastic surgery cannot match. 1 Since 2005, a total of 18 patients have received transplants with promising results. 2 – 7 Most facial transplantations have been designed to restore partial-face defects; full-face transplantations include the forehead, eyelids, nose, lips, chin, and cheeks, 8 , 9 with or without underlying bone. Full-face transplantation has been considered nearly impossible because of the complexity of the blood supply as well as ethical, psychological, and social implications. We report our initial experience in full-face . . .