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Lega, Dmitry A.; Chernykh, Valentine P.; Zaprutko, Lucjusz; Gzella, Andrzej K.; Shemchuk, Leonid A.
Chemistry of heterocyclic compounds (New York, N.Y. 1965), 02/2017, Letnik: 53, Številka: 2Journal Article
4,6-Dihydropyrano3,2- c 2,1benzothiazine 5,5-dioxides were synthesized via three-component interaction of 1-ethyl-1 H -2,1-benzothiazin-4(3 H )-one 2,2-dioxide with active methylene nitriles and cycloalkanecarbaldehydes. The latter were also applied to obtain ammonium salts of 3,3'-(cycloalkylmethanediyl)bis(1-ethyl-1 H -2,1-benzothiazin-4-ol) 2,2,2',2'-tetraoxides. The structures of the synthesized compounds were confirmed by 1 H, 13 C NMR as well as mass spectral and elemental analysis data. The structures of two representatives from each class of the target compounds have been additionally confirmed by single crystal X-ray diffraction study. The synthesized compounds were screened for antibacterial and antifungal activities.
