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Badigenchala, Sindhura; Ganapathy, Dhandapani; Das, Ankita; Singh, Rahul; Sekar, Govindasamy
Synthesis (Stuttgart), 01/2014, Letnik: 46, Številka: 1Journal Article
Abstract Biologically important bisindolylmethanes are synthesized in a domino fashion by using an iron(II) chloride–(±)-1,1′-binaphthyl-2,2′-diamine FeCl 2 –(±)-BINAM complex as the catalyst. This method proceeds via oxidation of a primary alcohol into the corresponding aldehyde followed by nucleophilic addition of an indole in the presence of the catalyst. A reaction intermediate is synthesized separately and converted into the bisindolylmethane product under the same reaction conditions as support for the proposed mechanism.
