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Manfrão‐Netto, João H. C.; Queiroz, Enzo Bento; Oliveira Junqueira, Ana C.; Gomes, Antônio M. V.; Gusmão de Morais, Daniel; Paes, Hugo Costa; Parachin, Nádia Skorupa
Journal of applied microbiology, February 2022, 2022-Feb, 2022-02-00, 20220201, Letnik: 132, Številka: 2Journal Article
Summary Hyaluronic acid (HA) is a biopolymer of repeating units of glucuronic acid and N‐acetylglucosamine. Its market was valued at USD 8.9 billion in 2019. Traditionally, HA has been obtained from rooster comb‐like animal tissues and fermentative cultures of attenuated pathogenic streptococci. Various attempts have been made to engineer a safe micro‐organism for HA synthesis; however, the HA titres obtained from these attempts are in general still lower than those achieved by natural, pathogenic producers. In this scenario, ways to increase HA molecule length and titres in already constructed strains are gaining attention in the last years, but no recent publication has reviewed the main genetic strategies applied to improve HA production on heterologous hosts. In light of that, we hereby compile the advances made in the engineering of micro‐organisms to improve HA synthesis.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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