No‐till (NT) is a sustainable option because of its benefits in controlling erosion, saving labor, and mitigating climate change. However, a comprehensive assessment of soil pH response to NT is still lacking. Thus, a global meta‐analysis was conducted to determine the effects of NT on soil pH and to identify the influential factors and possible consequences based on the analysis of 114 publications. When comparing tillage practices, the results indicated an overall significant decrease by 1.33 ± 0.28% in soil pH under NT than that under conventional tillage (p < .05). Soil texture, NT duration, mean annual temperature (MAT), and initial soil pH are the critical factors affecting soil pH under NT. Specifically, with significant variations among subgroups, when compared to conventional tillage, the soil under NT had lower relative changes in soil pH observed on clay loam soil (−2.44%), long‐term implementation (−2.11% for more than 15 years), medium MAT (−1.87% in the range of 8–16℃), neutral soil pH (−2.28% for 6.5 < initial soil pH < 7.5), mean annual precipitation (−1.95% in the range of 600–1200 mm), in topsoil layers (−2.03% for 0–20 cm), with crop rotation (−1.98%), N fertilizer input (the same for NT and conventional tillage) of 100–200 kg N ha−1 (−1.83%), or crop residue retention (−1.52%). Changes in organic matter decomposition under undisturbed soil and with crop residue retention might lead to a higher concentration of H+ and lower of basic cations (i.e., calcium, magnesium, and potassium), which decrease the soil pH, and consequently, impact nutrient dynamics (i.e., soil phosphorus) in the surface layer under NT. Furthermore, soil acidification may be aggravated by NT within site‐specific conditions and improper fertilizer and crop residue management and consequently leading to adverse effects on soil nutrient availability. Thus, there is a need to identify strategies to ameliorate soil acidification under NT to minimize the adverse consequences. A global meta‐analysis was conducted to indicate that NT could significantly reduce the soil pH. Variations in the soil pH among different regions and/or pedoclimatic conditions were observed. Combined with the model selection analysis, four essential drivers were confirmed. A higher concentration of H+ and lower basic cations may enhance the risk of NT to acidify the soil. Consequently, nitrogen and other soil nutrients were impacted, especially in the surface soil. Potential strategies to ameliorate soil acidification maybe the optimal combination of NT with site‐specific fertilization and crop residue management practices.