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Hunyadi, Laszlo; Datta, Palika; Rewers‐Felkins, Kathleen; Sundman, Emily; Hale, Thomas; Fajt, Virginia; Wagner, Sarah
Journal of veterinary pharmacology and therapeutics, 20/May , Letnik: 45, Številka: 3Journal Article
The objective of this study was to determine the pharmacokinetic parameters of oclacitinib maleate as a top dress given to adult horses. Six adult horses with a mean weight of 528 kg were administered a single dose of 0.5 mg/kg oclacitinib maleate. Blood was collected prior to drug administration and at 15 min, 30 min, 45 min, 1, 2, 4, 6, 8, 12, 24, 48, and 72 h after treatment. Oclacitinib maleate plasma concentrations were measured by liquid chromatography/mass spectrometry. Pharmacokinetic parameters were found best to fit a one‐compartment model. Mean Cmax was 486 ng/ml (range 423–549 ng/ml), and Tmax was estimated to be 1.7 h (range 0.3–3.1 h). The estimated T1/2 was 7.5–8 h.
