E-viri
Recenzirano
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Xie, Ming-Hong; Holcomb, Ilona; Deuel, Bethanne; Dowd, Patrick; Huang, Arthur; Vagts, Alicia; Foster, Jessica; Liang, Jie; Brush, Jennifer; Gu, Qimin; Hillan, Kenneth; Goddard, Audrey; Gurney, Austin L.
Cytokine (Philadelphia, Pa.), 10/1999, Letnik: 11, Številka: 10Journal Article
We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line.
