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Liu, Jieyu; Ding, Qiuping; Fang, Wenjun; Wu, Wanhui; Zhang, Yuanguang; Peng, Yiyuan
Journal of organic chemistry, 11/2018, Letnik: 83, Številka: 21Journal Article
A Pd/norbornene-catalyzed direct meta-alkylation of nosyl-protected phenylalanine derivatives with alkyl iodides is reported in moderate to good yields. The use of diisopropyl bicyclo2.2.1hept-5-ene-2,3-dicarboxylate is identified as a more suitable transient mediator. A simple pyridine ligand is also essential for this reaction to proceed. No racemization was observed in this meta-methylation reaction.
