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Datta, Palika; Ciplea, Andrea I; Rewers-Felkins, Kathleen; Baker, Teresa; Gold, Ralf; Hale, Thomas W; Hellwig, Kerstin
Multiple sclerosis, 04/2021, Letnik: 27, Številka: 5Journal Article
Background: Cladribine is an antimetabolite used for the treatment of relapsing–remitting multiple sclerosis. At present, there are no data available on its use in breastfeeding mothers and its transfer in human milk. Objective: We present a case of a lactating mother who donated her milk samples to study the transfer of cladribine following a 20-mg oral dose. Methods: Analysis was done using liquid chromatography–mass spectrometry. Results: The relative infant dose calculated in this study was 3.06%. Conclusion: This is the first case report suggesting the transfer of cladribine in human milk in measurable quantities. However, caution should be advised during lactation.
