The characterization of the thermophysical properties of new environmentally friendly fluids, such as hydrofluoroether fluids (HFEs) and their mixtures with other compounds, is necessary nowadays in order to properly design the machinery and piping networks involved in their utilization. However, scarce data concerning these kinds of fluids are actually available. In this work, new experimental high pressure density data (742 points) for the binary system x HFE-7100 + (1 – x) 1-propanol are presented. This property was measured by using an Anton Paar vibrating tube densitometer in the temperature range of 298.15–393.15 K and in the pressure interval of 0.1–70 MPa. A comparison between our experimental high pressure density data and those found in the literature was carried out only for the pure compounds, since no density data for the binary mixture were found. To perform this comparison, we used a Tait-like equation in order to correlate our results to those of the literature. Concerning the experimental density data, the derivative properties of isothermal compressibility, κT, and isobaric expansion, α P , were determined over the same pressure and temperature ranges. Excess molar volumes of the binary system were also determined and compared with those of the mixture x HFE-7100 + (1 – x) 2-propanol published in one of our previous works.