Epistaxis is a widespread, though usually bland, symptom of highly varying etiopathogenesis. ENT specialists face the challenge of selecting the best individual treatment modality when it recurs in connection with prominent vascular convolutions and angiectases in Kiesselbach's area (Little's spot), pyogenic granulomas of the nasal mucosa, intranasal hemangiomas or disseminated manifestations of Osler-Weber-Rendu's disease in the nasal cavity. Precise dosing and excellent visualization of the entire operating area render videoendoscopy-guided laser surgery an effective approach for sealing these hemorrhage-prone areas. In our clinically controlled prospective study, we examined the suitability of the fiber-guided diode laser for managing the most frequent causes of recurrent epistaxis, as mentioned above. Despite a still limited patient population, a close follow-up ranging up to 24 months has demonstrated the high therapeutic efficiency of this novel laser system (940 nm diode laser), which is already applied with great success for turbinate hyperplasia treatment, septal crest and spur vaporization and concha bullosa resection in functional endoscopic endonasal laser surgery (FEELS) (12a). Diode laser surgery of epistaxis-generating mucosa was usually performed using a bare-fiber-guided noncontact technique with the use of special glass-spatulas for compression and coagulation of vessels in outpatients under local anesthesia; using the chopped mode, moderate, individually adjusted powers were applied over short laser exposure times and relatively long exposure pauses.The diode laser did not differ in its therapeutic efficiency from the Argon or Nd:YAG laser, the two systems we preferred to use for this treatment during the last decade. But rega rds to its lower optical penetration and coagulation depth in combination with the use of different glass-spatulas, the diode laser appeared to involve a somewhat lower potential risk of wound-healing impairment. This is particularily significant compared to the “free hand-held treatment” without the compression and coagulation method and compared to the use of the Nd:YAG laser, especially at the nasal septum.