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Shpitz, Baruch; Stern, Hartley; Sandhu, Jas S.; Reilley, Raymond M.; Tropak, Michael B.; Jansz, Gwen; Xu, Jennis; Gallinger, Steven
The Journal of surgical research, 02/1996, Letnik: 61, Številka: 1Journal Article
Bispecific monoclonal antibodies can be used to redirect peripheral blood lymphocytes against tumor cells. In the present study, a murine bispecific monoclonal antibody was developed using somatic hybrydization. The antibody has two different binding arms: one arm directed against human CD3 receptor expressed on T-lymphocytes and the other against tumor associated glycoprotein TAG-72, expressed on human carcinomas, such as colon, breast, and pancreas. Partially purified antibody was capable of inducing human T-cell proliferation and preventing growth of colon cancer cell line in nu/nu mice in a tumor neutralization assay.
