Science has undergone remarkable changes both in scale, organization and influence over the last half century. It has changed the way we live and is more essential than ever before. Although the scientific effort today is more international than it was 50 years ago, only a small part of the world is fully engaged in this process. It is of course impossible in a single article to provide an overall balanced account of these developments and this is not an attempt to do so. Instead, certain trends are illustrated here, based solely on the personal experiences of an individual who – during a long career in the Life Sciences, and through work in many international science organizations – has been a witness and played a role in some of the changes that have occurred, often influenced by major political events.