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Li, Yaozong; Bedi, Rajiv K; Moroz-Omori, Elena V; Caflisch, Amedeo
Journal of chemical information and modeling, 12/2020, Letnik: 60, Številka: 12Journal Article
Three YTH-domain family proteins (YTHDF1, YTHDF2, and YTHDF3) recognize the N6-methyladenosine (m6A) modification of mRNA in cells. However, the redundancy of their cellular functions has been disputed. We investigate their interactions with m6A-containing RNA using X-ray crystallography and molecular dynamics (MD). The new X-ray structures and MD simulations show that the three proteins share identical interactions with the m6A-containing RNA and have similar intrinsic plasticity, thus evidencing the redundant roles of the three proteins in cellular functions.
