Introduction In everyday clinical neurophysiology practice, mononeuropathies are evaluated primarily by traditional electrodiagnostic testing. We sought to assess the additional benefit of neuromuscular ultrasound (US) in this scenario. Methods All consecutive mononeuropathies undergoing combined US and electrodiagnostic evaluation over a 23‐mo period at a single neurophysiology practice were reviewed. Three independent examiners assessed how often US was: (a) “contributory” ‐ enabling a definite diagnosis not made by electrophysiology alone and/or impacting on the therapeutic decision, (b) “confirmatory” of the electrodiagnostic findings, but not adding further diagnostic or therapeutic information, or (c) “negative” ‐ missed the diagnosis. Results There were 385 studies included. US was “contributory” in 36%, “confirmatory” in 61% and “negative” in 3%. Discussion In this study of everyday neurophysiology practice, neuromuscular US contributed significant diagnostic or therapeutic information in over 1/3 of the investigations for common mononeuropathies. False negative US studies were uncommon in this setting. See Editorial on pages 437–438 in this issue.