Bevacizumab added to neoadjuvant combination chemotherapy increased the rate of pathological complete response among patients with HER-2-negative early-stage breast cancer. The effect was greatest in patients with the poorest prognosis, those with so-called triple-negative tumors. The efficacy of neoadjuvant chemotherapy, as measured by the rate of pathological complete response (the absence of invasive and intraductal disease in the breast and the axillary lymph nodes), varies according to breast-cancer subtype. 1 When anthracyclines, taxanes, and agents directed against anti–human epidermal growth factor receptor 2 (HER2) (if indicated) are used, approximately 30 to 40% of all breast cancers that are HER2-positive or triple-negative (estrogen-receptor–negative, progesterone-receptor–negative, and no overexpression of HER2) are completely eradicated locally at the time of surgery. 2 – 6 Long-term follow-up studies have shown a consistent correlation between pathological complete response and low rates of relapse and . . .