In two randomized trials conducted under home conditions, investigators compared closed-loop insulin delivery with sensor-augmented pump therapy in adults and in children and adolescents for 12 weeks. The closed-loop approach improved glucose control and reduced hypoglycemia. Intensive insulin therapy is the standard of care for type 1 diabetes but is limited by the risk of hypoglycemia, 1 which leads to failure in achieving treatment goals for most patients in all age groups. 2 , 3 Among patients with type 1 diabetes, hypoglycemia is common, has a major effect on patients’ quality of life and psychological well-being, 4 and may cause seizures, which is of particular concern during the overnight hours in children and adolescents. 5 New approaches (e.g., continuous glucose monitoring) can improve glycemic control when the patient wears the sensors on a regular basis. 6 , 7 If insulin delivery is linked . . .