The results of a genomewide association study of generalized vitiligo implicate genes involved in the immune response and also a variant of TYR, which encodes tyrosinase. This variant of TYR encodes a protein that seems particularly likely to be detected by immune surveillance. The results of a genomewide association study of generalized vitiligo implicate genes involved in the immune response and also a variant of TYR, which encodes tyrosinase. Generalized vitiligo is a disease in which patchy depigmentation of skin and hair results from autoimmune loss of melanocytes. 1 , 2 It is a complex disorder involving multiple susceptibility genes and unknown environmental triggers. Genetic linkage and candidate-gene association studies have implicated several potentially contributory loci, though few have been consistently supported by the data. 3 Patients with generalized vitiligo have elevated frequencies of other autoimmune diseases, including autoimmune thyroid disease, rheumatoid arthritis, psoriasis, adult-onset type 1 diabetes, pernicious anemia, systemic lupus erythematosus, and Addison's disease, 4 suggesting that these diseases involve shared genetic components. To identify susceptibility loci for generalized vitiligo, we . . .