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Levy, Sonja; Korse, Catherina E.; Groot, Andre C. A.; Meijer, Ronald C. A.; Tesselaar, Margot E. T.; Valk, Gerlof D.
Journal of neuroendocrinology, October 2022, 2022-10-00, 20221001, Letnik: 34, Številka: 10Journal Article
Carcinoid heart disease (CHD) is a serious cardiac condition which is caused by elevated serotonin in the systemic circulation, secreted by neuroendocrine tumours (NET). It mostly affects the right‐sided heart valves, where it causes fibrotic disturbances and is associated with worse survival. In this study, we describe a large cohort of patients with CHD and provide an insight into their survival over the past decades. All consecutive patients with a serotonin producing NET and CHD referred to the Netherlands Cancer Institute that presented with CHD or developed CHD during their follow up time were included from 1984 until 2021. Patients were divided into three time periods: 1984–2000, 2000–2010 and 2010–2018. Median N‐terminal pro B‐type natriuretic protein (NT‐proBNP) and serum serotonin levels were stratified according to tricuspid regurgitation severity. Kaplan–Meier curves and log rank test were used for visualisation of survival. Cox regression was used for identification of the characteristics associated with disease specific mortality (DSM). A total of 84 patients with CHD were included of whom 49 (58.3%) were male. Median age at NET diagnosis was 62.3 (range 23.9–81.7) years, and median time to development of CHD was 1.1 (range 0–24.2) years. NT‐proBNP was significantly higher when more severe tricuspid regurgitation (TR) was present (p = .027). Median survival from CHD diagnosis for 1984–2000, 2000–2010 and 2010–2018 were 1.3 (confidence interval CI: 0.9–1.6), 1.9 (CI: 1.2–2.6) and 3.9 (CI: 1.7–6.2) years (p = .025). Valve replacement surgery (VSR) occurred more frequent in later time periods. VSR (hazard ratio HR 0.33, p = .005) and NT‐proBNP (HR 1.003, 1.00–1.005, p = .036) were significantly associated with DSM. The prognosis of patients with CHD has improved over the past decades, possibly caused by more VSR. NT‐proBNP is a valuable biomarker in patients with CHD. Clinical practice should be aimed at timely diagnosis and intervention of CHD.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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