Objectives The purpose of this qualitative descriptive research study was to understand the current state, perceived content, and experiential needs of pediatric nurses preparing for global health (GH) fieldwork experience. This study aimed to inform stakeholders about the standard and unique preparation needs of pediatric GH nurses. Study Design and Methods One group and five individual interviews were held with nurses from a large pediatric quaternary care facility in the Northeast United States. Data from the interviews were transcribed verbatim, eliminating personal data. Only deidentified transcripts were used for data analysis. Members of the study team used content analysis to systematically code and analyze the data. Results Qualitative content analysis revealed five categories: (1) identifying clear objectives, (2) understanding the practice environment, (3) self‐assessment of clinical skills, cultural competencies, and adaptability, (4) safety and logistics planning, and (5) psychological self‐care and reentry anticipatory guidance. Conclusions Findings can provide a basis for program planning to prepare pediatric nurses for GH fieldwork. Program planning must account for the unique features of the site and situation. Organizational and personal preparation can influence the perceived success of the GH experience.