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Seddon, Benedict; Yates, Andrew J.
Immunological reviews, September 2018, 2018-09-00, 20180901, Letnik: 285, Številka: 1Journal Article
Summary Generating and maintaining a diverse repertoire of naive T cells is essential for protection against pathogens, and developing a mechanistic and quantitative description of the processes involved lies at the heart of our understanding of vertebrate immunity. Here, we review the biology of naive T cells from birth to maturity and outline how the integration of mathematical models and experiments has helped us to develop a full picture of their life histories.
