ABSTRACT Taiwan renal care system is an evolving learning health‐care system. There are four facets of this system. From the early history of dialysis and Taiwan Renal Registry Data System, it facilitates the generation of data to knowledge. National multidisciplinary pre‐end‐stage renal disease care project and outcome enhances knowledge to practice. Early chronic kidney disease (CKD) programs and 2015 Taiwan CKD clinical guidelines implicate the practice to customer, and then explore the causes of CKD help to resume customer to data. A learning health‐care system allows better and safer care at lower cost, enhancement of public health and patient empowerment. The successful development of a learning health‐care system was to collect, accumulate and analyze data, interpret results, deliver tailored message and take action to change practice. Through the established database and data analysis, an integrated care system would be able to improve clinical outcomes and achieve the most cost‐effectiveness care. Acute kidney injury, CKD with unknown origin, palliative care and kidney transplant are our new focuses to struggle. Summary at a Glance Prevention of chronic kidney disease is an important public health issue in Taiwan. Through the four facets of this system, including data, knowledge, practice and customer, the experience of Taiwan Renal Data System is a success model of learning health‐care system.