Background Blepharoplasty is one of the most popular esthetic procedures with an acceptable risk profile and a relatively quick procedure. Methods The aim was to evaluate the efficacy and safety of a new CO2 and 1540‐nm laser‐assisted blepharoplasty technique applied to the upper and lower eyelids. A total of 38 patients were enrolled. Photographs were taken before the treatment and at 6‐month follow‐up. One “blind” observer assessed the performance of this technique by ranking the results in four categories of eyelid esthetic: 1 = no or poor results (0%–25%), 2 = slight improvement (25%–50%), 3 = moderate improvement (50%–75%) and 4 = marked improvement (75%–100%). All possible complications were monitored. Results Thirty‐two patients (84 %) achieved marked improvement, four patients (11%) moderate improvement, two patients (5 %) slight improvement, while zero subjects (0%) poor or no improvement. No serious adverse effects were observed. Conclusions Our results from clinical evaluations suggest that the CO2 and 1540‐nm laser assisted blepharoplasty is proved to be a sophisticate intervention efficacious in improving the treatment of patients with various degrees of eyelid and periocular aging and also in reducing downtime.