E-viri
Recenzirano
Odprti dostop
-
Leung, Daniel H.; Narang, Amrita; Minard, Charles G.; Hiremath, Girish; Goss, John A.; Shepherd, Ross
Liver transplantation, November 2016, 2016-11-00, 20161101, Letnik: 22, Številka: 11Journal Article
Young children < 2 years of age with chronic end‐stage liver disease (YC2) are a uniquely vulnerable group listed for liver transplantation, characterized by a predominance of biliary atresia (BA). To investigate wait‐list mortality, associated risk factors, and outcomes of YC2, we evaluated United Network for Organ Sharing registry data from April 2003 to March 2013 for YC2 listed for deceased donor transplant (BA = 994; other chronic liver disease CLD = 221). Overall, wait‐list mortality among YC2 was 12.4% and posttransplant mortality was 8%, accounting for an overall postlisting mortality of 19.6%. YC2 demonstrated 12.2%, 18.7%, and 20.6% wait‐list mortality by 90, 180, and 270 days, respectively. YC2 with CLD demonstrated significantly higher wait‐list mortality compared with BA among YC2 (23.9% versus 9.8%; P < 0.05). Multivariate analyses revealed that listing Pediatric End‐Stage Liver Disease PELD > 21 (hazard ratio HR, 3.2; 95% confidence interval CI, 1.6‐6.5), lack of exception (HR, 5.8; 95% CI, 2.8‐11.8), listing height < 60.6 cm (HR, 2.1; 95% CI, 1.4‐3.1), listing weight > 10 kg (HR, 3.8; 95% CI, 1.5‐9.2), and initial creatinine > 0.5 (HR, 6.8; 95% CI, 3.4‐13.5) were independent risk factors for YC2 wait‐list mortality (P < 0.005 for all). Adjusting for all variables, the risk of death among CLD patients was 2 (95% CI, 1.3‐3.1) times greater than patients with BA + surgery (presumed Kasai). Furthermore, the risk of death in BA surgery was 1.9 (95% CI, 1‐3.4) times greater than BA with presumed Kasai. Our data highlight unacceptably high wait‐list and early post–liver transplant mortality in YC2 not predicted by PELD and suggest key risk factors deserving of further study in this age group. Liver Transplantation 22 1584–1592 2016 AASLD.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.