Introduction The COVID‐19 pandemic has caused unprecedented disruptions to medical education. Education in medical specialties, such as otolaryngology faces multiple challenges, including reduced bedside and “hands‐on” training opportunities at all levels. Educators are turning to technological advancements to deliver effective remote medical education. This study investigated the value of enhancing traditional remote case‐based teaching with the HoloLens2™. Methods We present a randomized educational design study. All educational content, media, and learning outcomes were identical. Primary outcome measures included student performance as measured with pre‐ and post‐intervention quizzes and student engagement as measured by a tally‐mark system. Secondary outcome measures, collected using feedback questionnaires, included perceived enjoyment, engagement, and opinions regarding the educational role of this technology. Results The undergraduate medical students were randomized to either conventional or HoloLens2™ enhanced remote case‐based teaching (n = 56). HoloLens2™ enhanced teaching improved student performance by an average of 3 marks of 15% (p < 0.001). It was engaging and encouraged questions 4‐fold per session (p < 0.05) when compared to conventional remote case‐based teaching. There was no significant difference in overall objective measurements of engagement. Students taught using HoloLens2™ agreed that the teaching was enjoyable, effective in concept demonstration, and encouraged engagement. Conclusions Remote teaching has allowed for the continuation of medical education in uncertain times. Beyond COVID‐19, we predict that there will be a paradigm shift toward remote learning as new technological advancements emerges. These novel technologies may prove invaluable in the future potentially enabling education to be delivered between different hospitals, universities, and even overseas. Level of Evidence NA Laryngoscope, 133:1606–1613, 2023 The COVID‐19 pandemic has caused unprecedented disruptions to medical education. Educators are turning to technological advancements to deliver effective remote medical education. In this randomized educational design study, by comparing student engagement, knowledge transfer and student experience we investigate how mixed reality technology can enhance remote case‐based learning.