E-viri
Recenzirano
Odprti dostop
-
Constantinescu, Andrei-Emil; Bull, Caroline J; Jones, Nicholas; Mitchell, Ruth; Burrows, Kimberley; Dimou, Niki; Bézieau, Stéphane; Brenner, Hermann; Buchanan, Daniel D; D'Amato, Mauro; Jenkins, Mark A; Moreno, Victor; Pai, Rish K; Um, Caroline Y; White, Emily; Murphy, Neil; Gunter, Marc; Timpson, Nicholas J; Huyghe, Jeroen R; Vincent, Emma E
International journal of cancer, 01/2024, Letnik: 154, Številka: 1Journal Article
Observational studies have suggested a protective role for eosinophils in colorectal cancer (CRC) development and implicated neutrophils, but the causal relationships remain unclear. Here, we aimed to estimate the causal effect of circulating white blood cell (WBC) counts (N = ~550 000) for basophils, eosinophils, monocytes, lymphocytes and neutrophils on CRC risk (N = 52 775 cases and 45 940 controls) using Mendelian randomisation (MR). For comparison, we also examined this relationship using individual-level data from UK Biobank (4043 incident CRC cases and 332 773 controls) in a longitudinal cohort analysis. The inverse-variance weighted (IVW) MR analysis suggested a protective effect of increased basophil count and eosinophil count on CRC risk OR per 1-SD increase: 0.88, 95% CI: 0.78-0.99, P = .04; OR: 0.93, 95% CI: 0.88-0.98, P = .01. The protective effect of eosinophils remained OR per 1-SD increase: 0.88, 95% CI: 0.80-0.97, P = .01 following adjustments for all other WBC subtypes, to account for genetic correlation between the traits, using multivariable MR. A protective effect of increased lymphocyte count on CRC risk was also found OR: 0.84, 95% CI: 0.76-0.93, P = 6.70e-4 following adjustment. Consistent with MR results, a protective effect for eosinophils in the cohort analysis in the fully adjusted model RR per 1-SD increase: 0.96, 95% CI: 0.93-0.99, P = .02 and following adjustment for the other WBC subtypes RR: 0.96, 95% CI: 0.93-0.99, P = .001 was observed. Our study implicates peripheral blood immune cells, in particular eosinophils and lymphocytes, in CRC development, highlighting a need for mechanistic studies to interrogate these relationships.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.