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Syeda, Arshiya Banu; Syeda, Asra Banu; Ferazoddin, Mohammad; Paul, J. P.; Syed, Tasqeeruddin; Juluru, Bhasker
Synthetic communications, 09/2023, Letnik: 53, Številka: 17Journal Article
A new bunch of substituted aryl amino derivatives structurally modified pyrido3,2-dpyrimidines (10a-j) have been synthesized and evaluated for anticancer effects against PC3 (human prostate), A549 (human lung), MCF-7 (human breast) and Colo-205 (human colon) cancer cell lines by utilizing of MTT procedure. Most of the synthesized compounds were showed anticancer activity good to moderate activities with IC 50 values range from 0.013 ± 0.0058 µM to 8.22 ± 5.87 µM, whereas, standard 9 etoposide used as standard drug) showed IC 50 values from 0.14 ± 0.017 µM to 3.08 ± 0.135 µM, respectively. Among the synthesized compounds, five compounds 10a, 10b, 10c, 10d and 10e demonstrated more potent activity on all cell lines. Mainly, compound 10e displayed higher anticancer activity.
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