Flooding has become one of the most dangerous and expensive disasters due to urbanization and climate change. Tools for assessing flood impact are required to support the shift of flood mitigation management from post-disaster recovery and reconstruction to community-driven pre-disaster warning and preparation. This study aims to develop an integrated approach to spatially assess the economic and social losses and ecological gain and identify the geographical factors of locations with high impacts of floods in Brisbane using the datasets collected from both the 2011 and 2022 flood events. Water depth, inundated area, land cover, ecosystem service value, mortality, and morbidity were considered to assess flood impacts. It is found that downstream (above 23,500 m from the upper stream) riverside communities (within 800 m of the river) with low altitudes (below 15 m) are more likely to experience significant flood damage. Flood impacts have bell-shaped developments with elevation and direct distance to the upstream river source and an exponential decline with distances to the river. These findings have implications for formulating future urban land use and community-tailored mitigation strategies, particularly for flood warning and preparation.