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Palladini, Arianna; Thrane, Susan; Janitzek, Christoph M.; Pihl, Jessica; Clemmensen, Stine B.; de Jongh, Willem Adriaan; Clausen, Thomas M.; Nicoletti, Giordano; Landuzzi, Lorena; Penichet, Manuel L.; Balboni, Tania; Ianzano, Marianna L.; Giusti, Veronica; Theander, Thor G.; Nielsen, Morten A.; Salanti, Ali; Lollini, Pier-Luigi; Nanni, Patrizia; Sander, Adam F.
Oncoimmunology, 03/2018, Letnik: 7, Številka: 3Journal Article
Overexpression of human epidermal growth factor receptor-2 (HER2) occurs in 20-30% of invasive breast cancers. Monoclonal antibody therapy is effective in treating HER2-driven mammary carcinomas, but its utility is limited by high costs, side effects and development of resistance. Active vaccination may represent a safer, more effective and cheaper alternative, although the induction of strong and durable autoantibody responses is hampered by immune-tolerogenic mechanisms. Using a novel virus-like particle (VLP) based vaccine platform we show that directional, high-density display of human HER2 on the surface of VLPs, allows induction of therapeutically potent anti-HER2 autoantibody responses. Prophylactic vaccination reduced spontaneous development of mammary carcinomas by 50%-100% in human HER2 transgenic mice and inhibited the growth of HER2-positive tumors implanted in wild-type mice. The HER2-VLP vaccine shows promise as a new cost-effective modality for prevention and treatment of HER2-positive cancer. The VLP platform may represent an effective tool for development of vaccines against other non-communicable diseases.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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