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  • Improving clinical benefit ...
    Kwilas, Anna R; Gameiro, Sofia R; Kim, Peter S; Malamas, Anthony S; Hodge, James W

    Oncoimmunology, 06/2015, Letnik: 4, Številka: 6
    Journal Article

    Androgen-deprivation therapy (ADT) induces prostate cancer immunogenic modulation (IM) by reducing human tumor cell expression of anti-apoptotic genes thus facilitating increased sensitivity to immune-mediated lysis. Through its stimulation of IM, ADT has been shown to synergize with active immunotherapy thereby significantly improving overall survival in a mouse model of prostate cancer.