Eating disorders (EDs) are associated with high levels of distress, functional impairment, and morbidity. Perfectionism has been consistently identified as an important factor in the etiology and maintenance of disordered eating, and as a promising target for treatment efforts. To address the detrimental effects of perfectionism on disordered eating, further research is needed to better understand what mechanisms may influence the relationship between these variables. In the present research, we examined three constructs related to self-regulation as potential mediators of the relationship between perfectionism and disordered eating: positive self-compassion, distress tolerance, and social problem-solving. We collected data from a sample of racially and ethnically diverse undergraduate students (N = 280) using an online questionnaire battery. Using structural equation modeling (SEM), we developed measurement and structural models to meet criteria for good fit and tested the hypothesized relationships. Distress tolerance emerged as a robust, statistically significant mediator of the relationship between perfectionism and disordered eating. Social problem-solving and self-compassion did not mediate this relationship. Distress tolerance may counterbalance the cognitive load associated with perfectionism; freeing up mental resources to focus on resisting urges for immediate relief through engagement in maladaptive disordered eating. •Potential mediators between perfectionism and disordered eating were probed.•Distress tolerance emerged as robust, statistically significant mediator of this relationship.•Distress tolerance should be considered in future ED prevention and treatment endeavors.