E-viri
Recenzirano
Odprti dostop
-
Tremaroli, Valentina; Karlsson, Fredrik; Werling, Malin; Ståhlman, Marcus; Kovatcheva-Datchary, Petia; Olbers, Torsten; Fändriks, Lars; le Roux, Carel W.; Nielsen, Jens; Bäckhed, Fredrik
Cell metabolism, 08/2015, Letnik: 22, Številka: 2Journal Article
Bariatric surgery is currently the most effective procedure for the treatment of obesity. Given the role of the gut microbiota in regulating host metabolism and adiposity, we investigated the long-term effects of bariatric surgery on the microbiome of patients randomized to Roux-en-Y gastric bypass or vertical banded gastroplasty and matched for weight and fat mass loss. The two surgical procedures induced similar and durable changes on the gut microbiome that were not dependent on body mass index and resulted in altered levels of fecal and circulating metabolites compared with obese controls. By colonizing germ-free mice with stools from the patients, we demonstrated that the surgically altered microbiota promoted reduced fat deposition in recipient mice. These mice also had a lower respiratory quotient, indicating decreased utilization of carbohydrates as fuel. Our results suggest that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery. Display omitted •RYGB and VBG induce long-term alterations in the human gut microbiome•The changes in the microbiome do not depend on BMI•RYGB and VBG have different effects on bile acid and TMAO metabolism•The surgically altered microbiome contributes to fat mass regulation Bariatric surgery durably alters the human gut microbiome. Here, Tremaroli et al. demonstrate that two types of bariatric surgery, Roux-en-Y gastric bypass and vertical banded gastroplasty, produce long-term alterations of the gut microbiome independently of BMI and that these alterations modulate host metabolism and fat mass deposition.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.