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Singh, Ambrish; Venn, Alison; Blizzard, Leigh; March, Lyn; Eckstein, Felix; Jones, Graeme; Wirth, Wolfgang; Cicuttini, Flavia; Ding, Changhai; Antony, Benny
Rheumatology, 02/2024, Letnik: 63, Številka: 2Journal Article
To describe associations between MRI markers with knee symptoms in young adults. Knee symptoms were assessed using the WOMAC scale during the Childhood Determinants of Adult Health Knee Cartilage study (CDAH-knee; 2008-2010) and at the 6- to 9-year follow-up (CDAH-3; 2014-2019). Knee MRI scans obtained at baseline were assessed for morphological markers (cartilage volume, cartilage thickness, subchondral bone area) and structural abnormalities cartilage defects and bone marrow lesions (BMLs). Univariable and multivariable (age, sex, BMI adjusted) zero-inflated Poisson (ZIP) regression models were used for analysis. The participants' mean age in CDAH-knee and CDAH-3 were 34.95 (s.d. 2.72) and 43.27 (s.d. 3.28) years, with 49% and 48% females, respectively. Cross-sectionally, there was a weak but significant negative association between medial femorotibial compartment (MFTC) ratio of the mean (RoM) 0.99971084 (95% CI 0.9995525, 0.99986921), P < 0.001, lateral femorotibial compartment (LFTC) RoM 0.99982602 (95% CI 0.99969915, 0.9999529), P = 0.007 and patellar cartilage volume RoM 0.99981722 (95% CI 0.99965326, 0.9999811), P = 0.029 with knee symptoms. Similarly, there was a negative association between patellar cartilage volume RoM 0.99975523 (95% CI 0.99961427, 0.99989621), P = 0.014, MFTC cartilage thickness RoM 0.72090775 (95% CI 0.59481806, 0.87372596), P = 0.001 and knee symptoms assessed after 6-9 years. The total bone area was negatively associated with knee symptoms at baseline RoM 0.9210485 (95% CI 0.8939677, 0.9489496), P < 0.001 and 6-9 years RoM 0.9588811 (95% CI 0.9313379, 0.9872388), P = 0.005. The cartilage defects and BMLs were associated with greater knee symptoms at baseline and 6-9 years. BMLs and cartilage defects were positively associated with knee symptoms, whereas cartilage volume and thickness at MFTC and total bone area were weakly and negatively associated with knee symptoms. These results suggest that the quantitative and semiquantitative MRI markers can be explored as a marker of clinical progression of OA in young adults.
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