In this paper, we address the image denoising problem in presence of speckle degradation typically arising in ultra-sound images. Variational methods and Convolutional Neural Networks (CNNs) are considered well-established methods for specific noise types, such as Gaussian and Poisson noise. Nonetheless, the advances achieved by these two classes of strategies are limited when tackling the de-speckle problem. In fact, variational methods for speckle removal typically amounts to solve a non-convex functional with the related issues from the convergence viewpoint; on the other hand, the lack of large datasets of noise-free ultra-sound images has not allowed the extension of the state-of-the-art CNN denoiser methods to the case of speckle degradation. Here, we aim at combining the classical variational methods with the predictive properties of CNNs by considering a weighted total variation regularized model; the local weights are obtained as the output of a statistically inspired neural network that is trained on a small and composite dataset of natural and synthetic images. The resulting non-convex variational model, which is minimized by means of the Alternating Direction Method of Multipliers (ADMM) is proven to converge to a stationary point. Numerical tests show the effectiveness of our approach for the denoising of natural and satellite images. •An hybrid strategy for the despeckling problem combining convolutional neural networks and variational methods is proposed.•The proposed neural architecture is statistically-inspired and not requires the training on a large data-set of images.•A proof of convergence to a stationary point for the alternating direction method is given.