Front cover: When synaptogenesis begins, splicing of the Kalrn gene changes, leading to expression of several isoforms of this Rho GEF. One major isoform contains a phosphoinositide-binding amphipathic helix (cKal) preceding its Sec14 domain and a PDZ binding motif at the COOH-terminus (Kal7). Rat hippocampal neurons (22 DIV) expressing farnesylated-EGFP (fEGFP) were immunostained with antibodies specific for cKal (red), Vglut1 (blue) and GFP (green); the image is a compressed Z-stack. cKal localized to PSD-positive puncta apposed to Vglut1 positive presynaptic terminals. cKal7 differs from the other major Kal7 isoform (bKal7) in its localization and effect on spine morphology. Mutagenesis which eliminated the ability of cKal7 to interact with phosphoinositides altered its localization. Read the full article 'Alternate promoter usage generates two subpopulations of the neuronal RhoGEF Kalirin-7' by M. B. Miller, Y. Yan, Y. Wu, B. Hao, R. E. Mains and B. A. Eipper (J. Neurochem. 2017, vol. 140 (6), pp. 889-902) on doi: 10.1111/jnc.13749