Kentucky's wheat (Triticum aestivum L.) crop is planted into a rotation in which corn (Zea mays L.) is followed by wheat, which is followed by double‐crop soybean Glycine max (L.) Merr.. The causal agent of Fusarium head blight (FHB), Fusarium graminearum Schwabe, overwinters in corn stubble; thus, the Kentucky wheat crop is always at risk for FHB. The preeminent goal of the University of Kentucky wheat breeding program is releasing FHB‐resistant winter wheat cultivars. ‘Pembroke 2021’ (Reg. no. CV‐1198, PI 701381) is an early‐maturing, semi‐dwarf, soft red winter wheat cultivar developed and released in 2020 by the Kentucky Agricultural Experiment Station for FHB resistance, high yield and test weight potential, and lodging resistance. Pembroke 2021, tested as KY 07C‐1145‐94‐12‐5, was developed from the cross ‘IL99‐15867’/B990081//KY97C‐0554‐04‐05. The pedigree of the KY parent is VA94‐54‐549/Roane//Kristy. Pembroke 2021 was named for the Pembroke silt loam soil series prevalent in the main wheat‐producing area of Kentucky. Pembroke 2021 was selected from F4:5 head rows using a modified bulk breeding method; selected rows carried the resistance allele at the following FHB resistance quantitative trait loci: 1B Jamestown, 1A Neuse, 4A Neuse, and 3B Massey. Pembroke 2021 was tested in Kentucky in multi‐location replicated yield trials, the Uniform Eastern Soft Red Winter Wheat Nursery, the Mason‐Dixon nursery, the Uniform Northern Winter Wheat Scab Nursery, and the Kentucky Wheat Variety Trial. Core Ideas Scab resistance is essential in wheat cultivars grown in Kentucky. Small‐effect scab resistance QTL can be pyramided to confer acceptable resistance. Low deoxynivalenol levels are still the best indicator of effective scab resistance.