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  • Limonoids from the aerial p...
    Yang, Xue-Rong; Tanaka, Naonobu; Tsuji, Daisuke; Lu, Feng-Lai; Yan, Xiao-Jie; Itoh, Kohji; Li, Dian-Peng; Kashiwada, Yoshiki

    Tetrahedron, 12/2019, Letnik: 75, Številka: 52
    Journal Article

    Six new limonoids, munropins A−F (1–6), were isolated from the aerial parts of a Chinese medicinal plant, Munronia pinnata (Meliaceae). The structures of 1–6 were assigned by detailed analyses of their spectroscopic data. Munropins A (1) and B (2) are limonoids possessing a prieurianin skeleton with α,β-unsaturated γ-lactam moieties at C-17. Munropins C (3), D (4), and E (5) are also prieurianin type limonoids with an α,β-unsaturated γ-lactone moiety, an acetyl group, and an acetoxyacetyl group at C-17, respectively. Munropin F (6) was assigned as a nimbolinin type limonoid with a γ-hydroxy-α,β-unsaturated γ-lactone moiety. Display omitted •A Chinese traditional herbal medicine, Munronia pinnata, was studied.•Prieurianin and nimbolinin type limonoids were isolated from M. pinnata.•Their structures were elucidated by detailed spectroscopic analyses.•Munropins A and B are rare limonoids with γ-lactam moieties at C-17.