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Ma, Yue; Tsushima, Yamato; Sakuma, Mai; Sasaki, Shogo; Iida, Keisuke; Okabe, Sachiko; Seimiya, Hiroyuki; Hirokawa, Takatsugu; Nagasawa, Kazuo
10/2018, Letnik: 16, Številka: 4Journal Article
G-Quadruplex structures (G4s) in guanine-rich regions of DNA play critical roles in various biological phenomena, including replication, translation, and gene expression. The G4-forming DNAs can form three kinds of topologies, i.e. , parallel, anti-parallel, and hybrid. In this paper, we present G4 ligands L2H2-2M2EA-6OTD ( 3 ) and L2G2-2M2EG-6OTD ( 4 ) bearing tetra-aminoalkyl and -guanidinylalkyl side chains, respectively, in a macrocyclic hexaoxazole structure. These ligands efficiently induce the parallel-type topology of telomeric G4 regardless of the effects of cations. Titration with 4 results in a drastic topology switch to the parallel topology from the anti-parallel structure induced by the structurally related ligand L2H2-6OTD ( 1 ). Parallel type of topology in G4 is selectively induced by tetra-guanidinylalkyl substituted 6OTD derivative.
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