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Shanafelt, Tait D.; Parikh, Sameer A.; Noseworthy, Peter A.; Goede, Valentin; Chaffee, Kari G.; Bahlo, Jasmin; Call, Timothy G.; Schwager, Susan M.; Ding, Wei; Eichhorst, Barbara; Fischer, Kirsten; Leis, Jose F.; Chanan-Khan, Asher Alban; Hallek, Michael; Slager, Susan L.; Kay, Neil E.
Leukemia & lymphoma, 07/2017, Letnik: 58, Številka: 7Journal Article
Although preliminary data suggests that ibrutinib may increase risk of atrial fibrillation (AF), the incidence of AF in a general cohort of chronic lymphocytic leukemia (CLL) patients is unknown. We evaluated the prevalence of AF at CLL diagnosis and incidence of AF during follow-up in 2444 patients with newly diagnosed CLL. A prior history of AF was present at CLL diagnosis in 148 (6.1%). Among the 2292 patients without history of AF, 139 (6.1%) developed incident AF during follow-up (incidence approximately 1%/year). Older age (p < .0001), male sex (p = .01), valvular heart disease (p = .001), and hypertension (p = .04) were associated with risk of incident AF on multivariate analysis. A predictive model for developing incident AF constructed from these factors stratified patients into 4 groups with 10-year rates of incident AF ranging from 4% to 33% (p < .0001). This information provides context for interpreting rates of AF in CLL patients treated with novel therapies.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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