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Jandura, Allison; Krause, Henry M.
Trends in genetics, October 2017, 2017-10-00, 20171001, Letnik: 33, Številka: 10Journal Article
The past decade has seen a major increase in the study of noncoding RNAs (ncRNAs). However, there remains a great deal of confusion and debate over the levels of functionality and mechanisms of action of the majority of these new transcripts. This Opinion article addresses several of these issues, focusing particularly on long ncRNAs (lncRNAs). We reemphasize the unique abilities of RNAs to form myriad structures as well as to interact with other RNAs, DNA, and proteins, which provide them with unique and powerful abilities. One of these, the ability to interact sequence specifically with DNA, has been largely overlooked. Accumulating evidence suggests that evolution has taken advantage of RNA’s properties via the rapid acquisition of new noncoding genes in testes, with subsequent gains of function in other tissues. This amplification process appears to be one of the major forces driving metazoan evolution and diversity. The majority of RNAs transcribed by the human genome are in the form of long noncoding RNAs (lncRNAs). The number of lncRNAs with validated functions is growing exponentially. lncRNAs are associated with virtually all diseases. The number of lncRNA genes is proportional to organismal complexity. lncRNAs that regulate epigenetic processes act as DNA sequence-specific guides. The majority of lncRNAs are probably localized in the cytoplasm. The tissue with the highest levels and diversity of noncoding RNA expression is the testis. The majority of new lncRNA genes are believed to have evolved in the testis.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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