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Yang, Xun-Cai; Zeng, Chun-Mei; Avula, Srinivasa Rao; Peng, Xin-Mei; Geng, Rong-Xia; Zhou, Cheng-He
European journal of medicinal chemistry, 01/2023, Letnik: 245, Številka: Pt 1Journal Article
Unique coumarin aminophosphonates as new antibacterial agents were designed and synthesized to combat severely bacterial resistance. Bioactivity assessment identified that 3-hydroxylphenyl aminophosphonate 6f with low hemolytic activity not only exhibited excellent inhibition potency against Staphylococcus aureus at low concentration (0.5 μg/mL) in vitro but also showed considerable antibacterial potency in vivo. Meanwhile, the active compound 6f was capable of eradicating the S. aureus biofilm, thus alleviating the development of S. aureus resistance. Furthermore, the drug combination of compound 6f with norfloxacin could enhance the antibacterial efficacy. Mechanistic explorations manifested that molecule 6f was able to destroy the integrity of cell membrane, which resulted in the leakage of protein and metabolism inhibition. The cellular redox homeostasis was interfered through inducing the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS), leading to the reduction of glutathione (GSH) activity and lipid peroxidation. Furthermore, compound 6f could intercalate into DNA base pair to hinder normal biological function. The above results provided powerful information for the further development of coumarin aminophosphonates as antibacterial agents. Display omitted •Unique coumarin aminophosphonates with potent antibacterial efficacy were developed.•Molecule 6f exerted low toxicity, no obvious resistance and good bioavailability.•Compound 6f could disturb the membrane integrity and lead to the leakage of intracellular materials.•Compound 6f could induce oxidative damage and restrain metabolism.
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in: SICRIS
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