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Li, Yuanye; Cheng, Jingying; Li, Ying; Jiang, Yajing; Ma, Jiao; Li, Qinghua; Pang, Tianxiang
Biochemical and biophysical research communications, 05/2018, Letnik: 499, Številka: 3Journal Article
Acute myeloid leukemia (AML) blasts release a wide range of chemokines in which CXCL8 has recently been recognized to be important for tumor progression. To find out the function of CXCL8 in AML, we compared blood serum of AML patients and healthy donors and found that the average level of CXCL8 was higher in AML patients. Among patients, higher expression of CXCL8 was also a positive recurrence indicator which illustrated the critical role of CXCL8 in AML. Knocking down of CXCL8 in leukemic cell lines led to significant reduction of proliferation via inducing G0/G1 cell cycle arrest and apoptosis, which was accompanied by the inactivation of ERK1/2. Furthermore, inhibition of ERK1/2 by specific chemical inhibitors reconstructed the CXCL8 knocking down phenomenon. Overall, we demonstrated that expression level of CXCL8 had a positive relationship with recurrence probability in AML. And CXCL8 was strongly implicated in AML cells growth by activating the ERK1/2 signal pathway. •CXCL8 is significantly up-regulated in AML and correlates with poor prognosis.•CXCL8 promotes proliferation in AML cell lines by affecting cell cycle and apoptosis.•CXCL8 influences proliferation through ERK1/2 pathway.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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