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Fassan, Matteo; Brignola, Stefano; Pennelli, Gianmaria; Alberti, Giulia; Angerilli, Valentina; Bressan, Alessandra; Pellino, Antonio; Lanza, Cristiano; Salmaso, Roberta; Lonardi, Sara; Pucciarelli, Salvatore; Spolverato, Gaya; Scarpa, Marco; Realdon, Stefano; Farinati, Fabio; Luchini, Claudio; Rugge, Massimo; Loupakis, Fotios
Virchows Archiv : an international journal of pathology, 07/2020, Letnik: 477, Številka: 1Journal Article
Immunotherapy has been recently approved for gastric (GC) and gastroesophageal-junction adenocarcinomas (GEC), and PD-L1 immunohistochemical evaluation represents a promising predictive biomarker in this oncological setting. A series of 125 gastroesophageal dysplastic lesions (52 low-grade, 73 high-grade) was investigated for PD-L1 and DNA mismatch repair proteins status. PD-L1 was positive (combined positive score (CPS) ≥ 1) in 48 (31.0%) dysplastic lesions. A higher prevalence of PD-L1–positive cases was observed among esophageal specimens compared with gastric ones ( p = 0.0003), in high-grade and adenocarcinoma samples in comparison with low-grade dysplasia ( p < 0.0001), and in lesions with mismatch repair deficiency ( p = 0.028). For 30 dysplastic samples, a synchronous matched invasive lesion (GC = 15, GEC = 15) was available and tested for PD-L1 expression; a discordant PD-L1 status was observed in 12/30 (40%) cases. A relatively high prevalence in PD-L1 positivity was observed among gastroesophageal dysplastic lesions and this should be taken into consideration for future therapeutic strategies based on this biomarker.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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