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Dang, Phu Hoang; Nguyen, Hai Xuan; Duong, Truc Thanh Thi; Tran, Thao Kim Thi; Nguyen, Phuc Thi; Vu, Trang Kieu Thi; Vuong, Hung Chi; Phan, Nguyen Huu Trong; Nguyen, Mai Thanh Thi; Nguyen, Nhan Trung; Awale, Suresh
Journal of natural products (Washington, D.C.), 04/2017, Letnik: 80, Številka: 4Journal Article
From a CH2Cl2 extract of the bark of Taxus wallichiana, six new taxoids, wallitaxanes A–F (1–6), were isolated, together with 29 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. Wallitaxane D (4) was identified as an opened oxetane-type taxoid having the first naturally occurring C(H)-20 acetal group, while wallitaxanes E (5) and F (6) are representative of the rare abeo-taxoid class. The isolated compounds were evaluated for their α-glucosidase inhibitory activity and for cytotoxicity against the HeLa human cervical cancer cell line. In the present work, taxanes were found to exhibit α-glucosidase inhibitory activity for the first time, and wallitaxane A (1) showed the most potent effect, with an IC50 value of 3.6 μM. In turn, 7-epi-taxol (16) and 7-epi-10-deacetyltaxol (17) showed IC50 values of 0.05 and 0.085 nM, respectively, against HeLa cells.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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