There is now a growing body of evidence to suggest that patients with chronic disease experience their symptoms as a burden. Although symptoms are a principal focus for diagnosis and treatment of chronic obstructive pulmonary disease (COPD), there has been little research to date on symptom burden with reference to frequency, severity, and distress of symptoms. A descriptive, cross-sectional survey design was used. Symptom burden was measured using the Memorial Symptom Assessment Scale (MSAS). A sample of 214 patients with COPD, recruited from one of the major teaching hospitals in Ireland. Patients experienced a median of 13 symptoms. Patients with ‘very severe’ COPD experienced the greatest number, with a median of 15 symptoms, followed by those with ‘severe’ COPD, with a median of 14 symptoms. Patients with ‘mild’ and ‘moderate’ COPD reported a median of 10 symptoms each. The most burdensome symptoms were shortness of breath, lack of energy, difficulty sleeping, worrying, dry mouth, feeling nervous, and feeling irritable. Total symptom burden was found to be low. Patients with ‘very severe’ COPD had the greatest symptom burden, followed by those with ‘severe’, ‘moderate’, and ‘mild’ COPD. Symptom burden was higher for psychological symptoms, with a mean score of 1.60 compared to the physical symptoms (mean = 0.87). Patients with COPD experience a remarkably high number of symptoms, and significant symptom burden of both physical and psychological symptoms. There is a need for early assessment and management of both physical and psychological symptoms in all patients with COPD. •Patients with COPD experience problematic symptoms in their day-to-day lives.•The most problematic symptoms identified as a burden are not just the ‘cardinal’ symptoms of COPD. Patients experience symptom burden beyond these symptoms.•Patients with COPD not only experience physical symptom burden, but also psychological symptom burden. Psychological symptom burden was greater than physical symptom burden.•Symptom burden increases as COPD progresses.