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Cardoso, Elsa M.; Lourenço‐Gomes, Vânia; Esgalhado, André J.; Reste‐Ferreira, Débora; Oliveira, Nádia; Amaral, Ana Saraiva; Martinho, António; Gama, Jorge M. R.; Verde, Ignácio; Lourenço, Olga; Fonseca, Ana M.; Buchli, Rico; Arosa, Fernando A.
HLA : immune response genetics, December 2023, Letnik: 102, Številka: 6Journal Article
MHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma‐derived soluble human HLA class I molecules (sHLA class I), HLA class I serotypes and dementia. A cohort of HLA class I serotyped elderly subjects with no dementia/pre‐dementia (NpD, n = 28), or with dementia (D, n = 28) was studied. Multivariate analysis was used to examine the influence of dementia and HLA class I serotype on sHLA class I levels, and to compare sHLA class I within four groups according to the presence or absence of HLA‐A23/A24 and dementia. HLA‐A23/A24 and dementia, but not age, significantly influenced the level of sHLA class I. Importantly, the concurrent presence of HLA‐A23/A24 and dementia was associated with higher levels of sHLA class I (p < 0.001). This study has shown that the simultaneous presence of HLA‐A23/HLA‐A24 and dementia is associated with high levels of serum sHLA class I molecules. Thus, sHLA class I could be considered a biomarker of neurodegeneration in certain HLA class I carriers.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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