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Hugon-Rodin, Justine; Carrière, Camille; Claeyssens, Ségolène; Trillot, Nathalie; Drillaud, Nicolas; Biron-Andreani, Christine; Lavenu-Bombled, Cécile; Wieland, Anna; Flaujac, Claire; Stieltjes, Natalie; Lebreton, Aurélien; Brungs, Thomas; Hegglin, Andrea; Fiore, Mathieu; Desconclois, Céline; Gay, Valérie; Tardy-Poncet, Brigitte; Beurrier, Philippe; Barbay, Virginie; Chamouni, Pierre; Maistre, Emmanuel De; Simurda, Tomas; Casini, Alessandro
Journal of thrombosis and haemostasis, August 2023, 2023-Aug, 2023-08-00, 20230801, 2023-08, Letnik: 21, Številka: 8Journal Article
Women with hereditary fibrinogen disorders (HFDs) seem to be at an increased risk of adverse obstetrical outcomes, but epidemiologic data are limited. We aimed to determine the prevalence of pregnancy complications; the modalities and management of delivery; and the postpartum events in women with hypofibrinogenemia, dysfibrinogenemia, and hypodysfibrinogenemia. We conducted a retrospective and prospective multicentric international study. A total of 425 pregnancies were investigated from 159 women (49, 95, and 15 cases of hypofibrinogenemia, dysfibrinogenemia, and hypodysfibrinogenemia, respectively). Overall, only 55 (12.9%) pregnancies resulted in an early miscarriage, 3 (0.7%) resulted in a late miscarriage, and 4 (0.9%) resulted in an intrauterine fetal death. The prevalence of live birth was similar among the types of HFDs (P = .31). Obstetrical complications were observed in 54 (17.3%) live birth pregnancies, including vaginal bleeding (14, 4.4%), retroplacental hematoma (13, 4.1%), and thrombosis (4, 1.3%). Most deliveries were spontaneous (218, 74.1%) with a vaginal noninstrumental delivery (195, 63.3%). A neuraxial anesthesia was performed in 116 (40.4%) pregnancies, whereas general or no anesthesia was performed in 71 (16.6%) and 129 (44.9%) pregnancies, respectively. A fibrinogen infusion was administered in 28 (8.9%) deliveries. Postpartum hemorrhages were observed in 62 (19.9%) pregnancies. Postpartum venous thrombotic events occurred in 5 (1.6%) pregnancies. Women with hypofibrinogenemia were at an increased risk of bleeding during the pregnancy (P = .04). Compared with European epidemiologic data, we did not observe a greater frequency of miscarriage, while retroplacental hematoma, postpartum hemorrhage, and thrombosis were more frequent. Delivery was often performed without locoregional anesthesia. Our findings highlight the urgent need for guidance on the management of pregnancy in HFDs. •There are no epidemiologic data on pregnancy in hereditary fibrinogen disorders (HFDs).•We report an international study of 425 pregnancies in women with hypofibrinogenemia and dysfibrinogenemia.•The prevalence of live birth was high, without differences among the types of HFD.•Retroplacental hematoma, postpartum hemorrhage, and thrombosis were frequent.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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