Display omitted •2D borophene flatland is emerging suitable for high-performance application.•Developing functionalized borophene is suitable for efficient biosensing prototypes.•These systems can be translated for POC application.•IoMT and smartphone supported such systems are required for personalized healthcare. 2D-materials-based biosensing, supported by artificial intelligence (AI) and internet-of-medical things (IoMT), has emerged as a new technological platform for intelligent diagnostics at point-of-care (POC). To achieve a desired biosensing, high performance engineering in smart functionalized opto-electric 2D materials is crucial. Recently, borophene has emerged as one of such advanced platforms due to its high electroactive surface, anisotropic behaviour, high electron transport, controlled optical properties, feasibility of deposition in thin films, and possibility to generate surface functionalities. Although ease of fabrication still stands challenging, borophene could be deposited on flexible substrate, functionalized using chemistries to immobilize bio-actives, and control over electro-optical properties to develop a highly sensitive biosensing systems operated by smartphone to achieve early stage POC diagnosis. This letter is an attempt to project borophene for smart bio-sensing.